Supplementary Figure 5
From: Annotation-free quantification of RNA splicing using LeafCutter
Comparison between beta-binomial and Dirichlet-multinomial models for differential splicing analyses, performed on 10 male brain vs. heart samples from GTEx. Two approaches for combining per-intron p-values into cluster level introns are compared: Bonferroni correction and Fisher's combined test. Bonferroni is very conservative, as expected. Fisher's combined test has considerably lower power than the multinomial approaches. However, only v2 of the Dirichlet-multinomial (which uses a per intron concentration/overdispersion parameter) is well calibrated under permutations.
