Supplementary Figure 2: Influence of hypoxia on protein abundance.
From: Molecular landmarks of tumor hypoxia across cancer types
a–c, Comparison of tumor hypoxia scores generated from mRNA abundance and protein abundance data using the Buffa hypoxia signature for BRCA (breast invasive carcinoma) (a), OV (ovarian serous cystadenocarcinoma) (b) and COADREAD (colon adenocarcinoma and rectum adenocarcinoma) (c). Protein-abundance-based hypoxia scores were significantly correlated with mRNA-abundance-based hypoxia scores for all three tumor types. d, The abundance of ten proteins was significantly correlated with protein-based hypoxia scores across all three cancers (FDR < 0.05 in all three cancer types). nBRCA = 77 independent tumors, nOV = 102 independent tumors, nCOADREAD = 86 independent tumors for a–d. Spearman’s ρ was used to determine each correlation and P values were calculated using algorithm AS89.
