Supplementary Figure 7: S-CAP maintains a 41% decrease in VUS over 1000 Genomes superpopulations.
From: S-CAP extends pathogenicity prediction to genetic variants that affect RNA splicing
Each boxplot is defined so the centerline is at the median, the bottom of the box marks the 25th %-ile, the top of the box marks the 75th %-ile and the whiskers stretch to denote 1.5 times the interquartile range (IQR). S-CAP performance in reducing VUS is consistent across 5 different super populations from the 1000 genomes project despite European bias in the gnomAD control database. EUR, European (n = 503). AFR, African (n = 661). SAS, South Asian (n = 489). AMR, Ad Mixed American (n = 347). EAS, East Asian (n = 504).
