Extended Data Fig. 7: Human islets and EndoC-βH1 Glucose-Stimulated Insulin Secretion (GSIS). | Nature Genetics

Extended Data Fig. 7: Human islets and EndoC-βH1 Glucose-Stimulated Insulin Secretion (GSIS).

From: The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Extended Data Fig. 7

GSIS was assessed, in pancreatic human islets (a) and EndoC-βH1 cells (b). In the case of EndoC-βH1 cells, the experiments were performed upon exposure or not to IFNγ (1000 U/ml) +IL1β (50U/ml) for 48 h. Data are mean plus range of four to eight independent experiments, and are expressed as the ratio between glucose stimulated and basal insulin secretion. *P < 0.05, **P < 0.01, ***P < 0.001, for the indicated comparisons (paired t test (a) or ANOVA followed by Bonferroni correction (b)). NT = Non treated.

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