Extended Data Fig. 5: dACE2 and ACE2 expression in relation to IFNG expression in TCGA tumors and in cells treated with IFNγ. | Nature Genetics

Extended Data Fig. 5: dACE2 and ACE2 expression in relation to IFNG expression in TCGA tumors and in cells treated with IFNγ.

From: Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor

Extended Data Fig. 5

a, Expression levels of all IFN genes annotated in TCGA tumors (n = 10,185) were acquired from cBioPortal (https://www.cbioportal.org/); expression of IFNL4 was not annotated in this dataset. At RSEM ≥ 1, only expression of IFNG is common (61% samples), with mean RSEM = 19.8 compared to other IFN genes (mean RSEM ≤ 1.3). b, and c, Pearson correlation coefficients (r) for dACE2 and ACE2 vs. IFNG expression across tumors. dACE2 showed significant positive correlations (r ≥ 0.2) with IFNG in 8 tumor types, while ACE2 showed mainly negative correlations and only one positive correlation in breast cancer (r = 0.15). Expression values for dACE2 and ACE2 were based on log2-normalized exon read counts (Ex1b and Ex1c) and for IFNG—on RSEM values. d, Treatment of cell lines with IFNγ (2 ng/ml for 24 hrs) induced expression of dACE2 but not ACE2 in T84 cells. The results are presented with means + /- SD for three biological replicates; P-values are for the unpaired, two-sided Student’s T-tests.

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