Extended Data Fig. 9: Estimated RBP dysregulation effects are robust after conditioning on conserved genomic elements. | Nature Genetics

Extended Data Fig. 9: Estimated RBP dysregulation effects are robust after conditioning on conserved genomic elements.

From: Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk

Extended Data Fig. 9

The per-SNP heritability effect sizes (Ï„*) for each RBP dysregulation is plotted across the five major psychiatric disorders after inclusion of vertebrate, mammal and primate conserved phastCons elements to the conditioning baseline annotation set (including QTL annotations). The dashed line indicates RBP models below FDR 0.05 threshold after multiple hypothesis correction (jackknife one-sided p-values; Benjamini-Hochberg correction).

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