Extended Data Fig. 4: WGS integration with TAD boundaries altered in T-ALL.
From: Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia
a, b) Overlap of altered TAD boundaries as in Fig. 3c, d with genomic inversions (a) or insertions/deletions (indels) (b) from WGS of T-ALL 1 (top) and T-ALL 2 (bottom). Overlap was determined by bedtools intersect, using a 1 bp overlap for indels and 100 kb for individual inversion breakpoints (instead of the entire genomic range affected by the inversion). c) Overlap of individual translocation breakpoints (calculated from T-ALL Hi-C samples as in Supplementary Fig. 1B) with TAD boundaries displaying changes in TAD insulation between T cells and T-ALL. Overlap was determined by bedtools intersect, using a 1 bp overlap.
