Extended Data Fig. 3: Scatter plots of association P-values from SAIGE-GENE versus SMMAT and EmmaX-SKAT for the Burden, SKAT, and SKAT-O tests based on simulation data on the -log10 scale. | Nature Genetics

Extended Data Fig. 3: Scatter plots of association P-values from SAIGE-GENE versus SMMAT and EmmaX-SKAT for the Burden, SKAT, and SKAT-O tests based on simulation data on the -log10 scale.

From: Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts

Extended Data Fig. 3

1,000,000 genes were tested with 1,000 families, each having 10 members, as shown in the Supplementary Fig. 1. The Pearson’s correlation coefficients r2 > 0.99 for -log10(P-values) between SAIGE and SMMAT and between SAIGE and EmmaX-SKAT. a, h2 = 0.2. b, h2 = 0.4.

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