Extended Data Fig. 1: Overexpression of Sox2 and loss of Trp53/Cdkn2a give rise to esophageal squamous cell carcinoma (ESCC).
From: Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence
a, Immunoblots and quantification of p63 expression in four engineered organoids (normalized to Ī²-actin) (representative image from 2 independent experiments). b, Immunoblots of Sox2 in mouse organoids, human ESCC cell lines and a normal esophageal epithelium cell line EPC2 (representative image from 2 independent experiments).
