Extended Data Fig. 1: Birth weight, offspring birth weight mothers and gestational age.
From: Distinction between the effects of parental and fetal genomes on fetal growth
a,b, Effect estimates for fetal growth variants for gestational age vs. birth weight(adj for gestational age) in the Icelandic fetal (a) and maternal (b) GWAS analysis. Error bars shown for sequence variants with P < 5.1 × 10−4 in the corresponding birth weight analysis represent 95% CI. Effect estimates for gestational age were obtained by linear regression of gestational age against fetal growth variants in the Icelandic data. Effects are shown for the birth weight increasing allele based on the Icelandic fetal and maternal data, respectively. c,d, P-values for the fetal growth variants for the birth weight and birth weight mothers analysis with and without adjusting for gestational age. The log10 P-values of birth weight with and without adjusting for gestational age in the Icelandic fetal GWAS data (n = 125,541) (c). The log10 P-values of birth weight with and without adjusting for gestational age in the Icelandic maternal GWAS data (n = 59,735) (d). The name of the nearest gene is shown in black if P < 5 × 10−8. Note that for the COL27A1 variant the birth weight increasing allele in the Icelandic data differs from the one in the birth weight meta-analysis. The dashed grey line represents results from a simple linear regression using MAF (1 - MAF) as weights and the solid grey line indicates the reference line with slope = 1. GA, gestational age; BW, birth weight; OS, offspring.
