Extended Data Fig. 1: Overview of this study.
From: A cross-population atlas of genetic associations for 220 human phenotypes
We performed 220 deep-phenotype GWASs in BioBank Japan, including 108 novel GWASs ever conducted in East Asian population. We performed trans-biobank meta-analyses with UK Biobank and FinnGen (ntotal = 628,000), resulting in discovery of 5,343 novel loci. All summary statistics are openly shared through pheweb.jp web portal. As downstream analyses, we performed (i) cross-population comparison of pleiotropy and genetic correlation, (ii) comprehensive HLA fine-mapping, and (iii) statistical decomposition of a matrix of summary statistics to gain insights into biology underlying current disease classifications, by incorporating functional genomics, metabolomics, and biomarker data.
