Extended Data Fig. 7: Investigating chromatin bivalency in vivo and in human tumors.
From: H3K27me3 conditions chemotolerance in triple-negative breast cancer
a-c. Barplot displaying the top pathways enriched in H3K27me3/H3K4me3 bivalent genes identified in the human tumor sample from Patient_95 or in the corresponding PDX model PDX_95 (a), Patient_39/PDX_39 (b) or Patient_172/PDX_172 (c). d-f. Venn diagram displaying the intersection of the pathways enriched in H3K27me3/H3K4me3 bivalent genes identified in the untreated cells in the human sample from Patient_95 and its corresponding PDX model (d), Patient_39/PDX_39 (e) or Patient_172/PDX_172 (f). g. H3K27me3 and H3K4me3 chromatin profiles of KLF4 in 8 human tumor samples. The percentage of tumoral cells are indicated for each sample. h. Dotplot showing the top pathways enriched in genes displaying a dual H3K27me3 and H3K4me3 enrichment in the human tumor samples from MSigDB c2_curated KEGG and c5_GO annotations. Color of the dot corresponds to adjusted p-values, calculated with hypergeometric test adjusted for multiple testing, and the size of the dot corresponds to the gene ratio.
