Fig. 6: Distinct cell types can share similar heterochromatin landscapes.
From: Single-cell sortChIC identifies hierarchical chromatin dynamics during hematopoiesis
a, Double-incubation experiment produces cuts associated with either H3K4me1 or H3K9me3 (H3K4me1 + H3K9me3). b, UMAP representation of the H3K4me1 + H3K9me3 landscape in unenriched and lineage-negative cells in the BM. c, Schematic of how the standard single-incubated data can produce a model of which cluster-pair (one from H3K9me3, the other from H3K4me1) generates the observed double-incubated data. d, Output of cluster-pair predictions from H3K4me1 + H3K9me3 double-incubated cells. Cells are colored by their predicted H3K9me3 clusters. e,f, UMAP representation of the H3K4me1 + H3K9me3 landscape, colored by their predicted H3K9me3 cluster (e) or H3K4me1 cluster (f).
