Extended Data Fig. 4: T2D affects chromatin accessibility more profoundly in beta cells than in other endocrine cell types.
(a) Volcano plot showing differential cCREs in beta cells between type 2 diabetic (T2D) and non-diabetic donors. Panels show all beta cells (left), beta cells down-sampled to 15,000 (middle), and 5,000 cells (right). Each dot represents a cCRE. cCREs with FDR < .1 after Benjamini-Hochberg correction (red dots) were considered differentially accessible. (b) Volcano plot showing differential cCREs in alpha cells between T2D and non-diabetic donors. Panels show all alpha cells (left), alpha cells down-sampled to 15,000 (middle), and 5,000 cells (right). Each dot represents a chromatin accessible cCRE. cCREs with FDR < .1 after Benjamini-Hochberg correction (red dots) were considered differentially accessible. (c) Volcano plot showing differential cCREs in delta cells between T2D and non-diabetic donors. Panels show all delta cells (left) and delta cells down-sampled to 5,000 cells (right). Each dot represents a chromatin accessible cCRE. cCREs with FDR < .1 after Benjamini-Hochberg correction (red dots) were considered differentially accessible.
