Fig. 1: Sr43 encodes a protein kinase fused to two DUFs.
From: The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase
a, Th. elongatum chromosome 7. b, Schematic diagram of the wheat–Thinopyrum translocation chromosome. c, Identified EMS mutations along the predicted Sr43 gene model. d, Schematic diagram of Sr43, showing predicted domains and amino acid changes induced by the EMS mutations. e, Three-dimensional model of Sr43, as predicted by AlphaFold. Green, kinase; orange and blue, DUF domains; yellow, flexible linkers. f, Structural detail (dashed box in e) of a high-confidence ATP-binding site (red residues) in DUF668 bound to an ATP molecule, as determined by the small molecule docking program HADDOCK28. ATP is depicted as a stick structure (light green) connected to DUF668 residues by hydrogen bonds (red lines).
