Extended Data Fig. 4: Forest plots of DNMT3A burden associations with secondary smoking phenotypes.
From: Rare coding variants in CHRNB2 reduce the likelihood of smoking
The forest plots display the cohort-level or meta-analysis associations of DNMT3A pLOF plus missense burden mask (AAF<0.01) with binary and quantitative smoking phenotypes (major smoking phenotypes and phenotypes derived based on the UKB lifestyle questionnaire) and smoking-related diseases tested using REGENIE (Methods). The odds ratios (or beta estimates) and 95% confidence intervals are plotted. The columns ‘case counts’ and ‘control counts’ show the case and control sample sizes, respectively, broken down to the number of carriers of the homozygous reference, heterozygous and homozygous alternative genotypes.
