Fig. 3: Forest plots of the top burden–trait associations of the significant genes.
From: Rare coding variants in CHRNB2 reduce the likelihood of smoking
Cohort-level and meta-analysis summary statistics of the most significant burden–trait associations for each of the three exome-wide significant genes are summarized using forest plots. The ORs and 95% CIs are plotted. The columns ‘case counts’ and ‘control counts’ show the case and control sample sizes, respectively, broken down to the number of carriers of the homozygous reference, heterozygous and homozygous alternative genotypes. For burden definitions, refer to Supplementary Table 2. ALL, all ancestries; AAF, alternative allele frequency (combined frequency of all the variants aggregated in the burden mask).
