Extended Data Fig. 3: Sub-clustering of major cell groups and integration of scRNA and scATAC datasets. | Nature Genetics

Extended Data Fig. 3: Sub-clustering of major cell groups and integration of scRNA and scATAC datasets.

From: Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases

Extended Data Fig. 3

(a) UMAP representations of sub-clustered major cell groups using scATAC data. Cell compartments are labeled on the left, and cells are colored according to their high-resolution cluster labels. (b) UMAP representations of sub-clustered major cell groups using scRNA data. Cell compartments are labeled on the right, and cells are colored according to their high-resolution cluster labels. (c) scRNA gene expression for selected marker genes for each high-resolution scRNA-seq cluster from each sub-clustered cell group. The color indicates the relative expression across all high-resolution clusters and the size of the dot indicates the percentage of cells in that cluster that express the gene. (d) Correspondence between scRNA and scATAC-seq cluster labels for high-resolution clusters in each of the sub-clustered datasets. Heatmaps are colored according to the Jaccard index of cluster label overlap between the scRNA and scATAC-seq datasets. (e) Correspondence between scRNA and scATAC-seq cluster labels in the full scalp dataset.

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