Extended Data Fig. 5: Association of the GPS at increments of 0.3 with drug indication in the Open Target and SIDER dataset in drugs with one gene target.
From: Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications
The association of increasing GPSs with drug indications was investigated by binning the Open Target drug dataset (n = 215,028 independent drug-gene-phenotype combinations) and the SIDER dataset (n = 66,792 independent drug-gene-phenotype combinations) into 0.3 increments of the GPS and comparing GPSs greater or equal to each increment with GPSs equal to zero. For each bin, a logistic regression model was performed with drug indication as the outcome variable and the GPS bin as the predictor variable, adjusting for phecode categories as covariates. We show the ORs with 95% CI from the logistic regression model assessed in the Open Targets and SIDER dataset, restricted to drugs with one gene target. ORs with 95% CI are defined in the forest plots as circles and error bars.
