Extended Data Fig. 7: Neoantigen silencing due to HLA LOH and repression. | Nature Genetics

Extended Data Fig. 7: Neoantigen silencing due to HLA LOH and repression.

From: MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution

Extended Data Fig. 7

For each tumor region, the fraction of putative neoantigens predicted to bind exclusively to HLA alleles subject to LOH and/or repression. Boxplot shows median and first and third quartiles, and whiskers extend up to 1.5× IQR above and below the IQR. LOH: loss of heterozygosity; LUAD: lung adenocarcinoma; LUSC: lung squamous cell carcinoma.

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