Extended Data Fig. 9: Trans-sQTL analysis revealed a regulatory relationship between hnRNPLL and PTPRC. | Nature Genetics

Extended Data Fig. 9: Trans-sQTL analysis revealed a regulatory relationship between hnRNPLL and PTPRC.

From: Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases

Extended Data Fig. 9

(a) Colocalization between hnRNPLL cis-eQTL and PTPRC trans-sQTL. We identified colocalization (H4 > 0.75) in GZMBhi CD8+ T, GZMKhi CD8+ T, and GZMKhi γδ T cells. Unadjusted two-sided P values were obtained using Matrix eQTL (eQTL) and QTLtools (sQTL). (b) Violin plot showing the cell-type-specific effect of hnRNPLL cis-eQTL and PTPRC trans-sQTL. The minor allele of rs6751481 leads to a lower expression of hnRNPLL (upper panel) and a lower expression of CD45RO isoform (lower panel). Unadjusted two-sided P values were obtained using Matrix eQTL (upper) and QTLtools (lower). The number of donors for each genotype is shown under each violin plot. The box plots show median and IQR, and whiskers are 1.5-fold IQR. Red lines indicate significant linear relationship between intron usage and genotype.

Back to article page