Fig. 4: HHV-6 epitope mapping of antibodies in patients with SLE.
From: Blood DNA virome associates with autoimmune diseases and COVID-19
a, Detection of epitopes on HHV-6 proteins. Means of the PhIP-seq scores of the indicated participant groups are shown. Each dot shows a score for a peptide split by a 14 amino acids sliding window applied to HHV-6A and HHV-6B proteins. Specific proteins of interest are labeled. b, Detection of epitopes on the three HHV-6B proteins. Copy numbers of immunoprecipitated phage genomes encoding HHV-6B peptides are shown as a heatmap. Three HHV-6B proteins that harbor abundant epitopes are shown. The region of the IE-A transactivator associated with eHHV-6B positivity is labeled with an orange arrow (amino acids 476–490). c, Statistical association between the presence of eHHV-6 and the copy numbers of immunoprecipitated phage genomes encoding HHV-6 peptides. IE-A transactivator amino acids 476–490 are labeled in orange. Uncorrected P values from the two-sided Wald test are shown. Red horizontal lines show the threshold of P (<0.05) after Bonferroni correction. IS, immunosuppressant use; NC, no antibody control; M, male; F, female.
