Extended Data Fig. 3: Comparison of P-value distribution between HDL-L and LAVA under the null hypothesis.
From: An enhanced framework for local genetic correlation analysis
We considered six different heritability combinations of the two phenotypes: \({h}_{1}^{2}=0.2,\,{h}_{2}^{2}=0.4\); \({h}_{1}^{2}=0.2,\,{h}_{2}^{2}=0.8;\) \({h}_{1}^{2}=0.6,\,{h}_{2}^{2}=0.8\); \({h}_{1}^{2}=0.3,\,{h}_{2}^{2}=0.3;\) \({h}_{1}^{2}=0.5,\,{h}_{2}^{2}=0.5;\) \({h}_{1}^{2}=0.7,\,{h}_{2}^{2}=0.7\). The true genetic correlation (\({r}_{G}\)) was set at 0 (null hypothesis). 10% of SNPs were randomly selected as causal SNPs.
