Fig. 3: Genetic correlations between female infertility and other phenotypes. | Nature Genetics

Fig. 3: Genetic correlations between female infertility and other phenotypes.

From: Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Fig. 3

SNP-based genetic correlations (rg) between significantly heritable phenotypes (Z > 4) were estimated using LD-score regression, performed using the LDSC software on a subset of 1 million HapMap3 SNPs. The points are colored by rg estimate, scaled by significance (−log10(P)), and labeled with the associated rg estimate if nominally significant without correction for multiple testing (P < 0.05). a, Genetic correlations among three definitions of female infertility (F-ALL, F-ANOV and F-INCL). b, Genetic correlations between female infertility traits and reproductive hormones testosterone, FSH and AMH (publicly available summary statistics) in female-specific analyses and TSH (publicly available summary statistics) from sex-combined analysis. c, Genetic correlations between female infertility traits and female reproductive conditions, with summary statistics generated from the largest available EUR-ancestry studies for each trait (Methods). d, Genetic correlations between female infertility traits and selected heritable phenotypes (Z > 4) in the UKBB, as generated by the Neale laboratory. Correlations with all heritable phenotypes can be found in Supplementary Table 12.

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