Extended Data Fig. 7: Association of tumor mutational burden and fraction of genome altered with overall survival, progression free survival, and immunotherapy response.

Forest plots depicting multivariable regression models examining associations with overall survival in Cox multivariable regression (a), progression-free survival in Cox multivariable regression (b), and tumor response to immunotherapy in logistic regression (c). Covariates in the models included tumor mutational burden (TMB), fraction of genome altered (FGA), cancer stage, and cancer type. Hazard or odds ratios with 95% confidence intervals and corresponding p-values are shown on the right.