Fig. 3: Characterization of PESs. | Nature Genetics

Fig. 3: Characterization of PESs.

From: Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs

Fig. 3

a, Pile-up results of GM12878 PES genes (left, n = 819), length-distribution-matched non-PES genes (left center, n = 819) and the difference between stripy and nonstripy genes at 1-kb resolution (right center). Right, pile-up results, rescaled between the TSS and the TTS. b, Cumulative curves of expression level for PES and non-PES genes of GM12878. A two-sided Mann–Whitney U test was used. c, Metagene plots of mean H3K27ac signal of stripy and nonstripy genes of GM12878. d, Metagene plots of mean RAD21 signal of PES and non-PES genes of GM12878. e, Pile-up results of PES genes (n = 853) for untreated, RAD21-depleted and WAPL-depleted Micro-C data from mESC at 1-kb resolution. Signal value along the TSS is shown on the far right. Data are from ref. 49. f, Cartoon model depicting cohesin-mediated loop extrusion facilitating the scanning of downstream enhancers by the promoter.

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