Extended Data Fig. 6
From: Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase
Comparison of the binding of K-X-X-R binding mode (SIL1) with that of a, R-F-S-R binding mode (OR51B2), b, G-R-A-R (Clone13), and c, K-X-X-RG (SIL1_R/RG). In (a)–(c), the SIL1 peptide is shown in yellow ribbon, with key reisdues shown in sticks. The SIL1 interaction residues of FEM1C are shown in blue sticks. The peptides of OR51B2, Clone13, and SIL1_R/RG are shown in gray ribbon, with key residues shown in sticks. The FEM1C residues that interact with OR51B2, Clone13, or SIL1_R/RG are shown in grey sticks. Different conformations of key residues are highlighted by red circles.
