Extended Data Fig. 1: Reprogramming competence of OCT factors in humans.
From: Permissive epigenomes endow reprogramming competence to transcriptional regulators
a, A schematic representation of eight OCT proteins. The numbers indicate the length of amino acids. N-TAD, N-terminal transactivation ___domain; DBD, DNA-binding ___domain; C-TAD, C-terminal transactivation ___domain. The DBD has a bipartite structure with two subdomains, POU-specific ___domain (red) and POU-homeodomain (blue), which are connected by a linker (green). b, Among eight OCT family members, only OCT4 and OCT6 were reprogramming-competent. P value was 0.0002. Data are presented as mean values ± s.d. (b, n = 3 biologically independent samples). Differences between samples were compared using a two-tailed Student’s t-test (***P < 0.001).
