Fig. 2: Cryo-EM structures of hSTING bound to NVS-STG2.
From: Activation of human STING by a molecular glue-like compound
a, Induction of STING oligomerization by cGAMP, C53, NVS-STG2 and their different combinations. STG2, NVS-STG2. One representative gel from three replicates is shown. b, Micrographs of STING bound to cGAMP/NVS-STG2 or cGAMP/NVS-STG2/C53. Images shown are representatives from n = 3,352 and n = 4,921 images for the cGAMP/NVS-STG2 and cGAMP/NVS-STG2/C53 samples, respectively. Arrows highlight STING oligomers. c, Cryo-EM density map and atomic model of STING bound to cGAMP/NVS-STG2. d, Cryo-EM density map and atomic model of STING bound to cGAMP/NVS-STG2/C53. TM, transmembrane.
