Fig. 3: Details of the binding mode of NVS-STG2.
From: Activation of human STING by a molecular glue-like compound
a, Overviews of the binding modes of NVS-STG2 (STG2) and C53. b, Detailed views of the NVS-STG2-binding site. c, Reponses of hSTING to NVS-STG2, with key binding pocket mutations. The x axis represents the concentration of NVS-STG2 in log scale. d, Activation of hSTING R95 mutants by STG2. In c and d, data are mean and s.e.m. from three biological replicates.
