Extended Data Fig. 6: Map quality of the DCAF16-BRD4BD2-MMH2 interface.
From: Template-assisted covalent modification underlies activity of covalent molecular glues
a. Cryo-EM density for DCAF16 containing Cys58 covalently bound to MMH2. Map contoured at 0.251. b. Cryo-EM density for DCAF16. c. Cryo-EM density for BRD4BD2. d. Overlay of MMH2 with JQ1 (PDB: 3ONI, in white). e. Key residues on DCAF16 (in green and blue) and BRD4BD2 (in magenta) close to MMH2.
