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Biological functions of DEAD/DEAH-box RNA helicases in health and disease

Nature Immunology volume 23, pages 354–357 (2022)Cite this article

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On 15–16 November 2021, the National Institute of Allergy and Infectious Diseases (NIAID), the National Cancer Institute (NCI) and the National Heart, Lung, and Blood Institute (NHLBI) hosted a virtual workshop on DEAD/DEAH-box RNA helicases in health and disease. The goal of the workshop was to review current advances, and identify knowledge gaps and future research to improve our understanding of the function of RNA helicases, and leverage these molecules as molecular targets with translational potential.

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Fig. 1: Phylogeny of human DEAD/DEAH-box RHs.
Fig. 2: Immuno-therapeutic considerations of RHs.

References

  1. Bourgeois, C. F., Mortreux, F. & Auboeuf, D. Nat. Rev. Mol. Cell Biol. 17, 426–438 (2016).

    Article  CAS  Google Scholar 

  2. Rocak, S. & Linder, P. Nat. Rev. Mol. Cell Biol. 5, 232–241 (2004).

    Article  CAS  Google Scholar 

  3. Chow, K. T., Gale, M. Jr & Loo, Y. M. Annu. Rev. Immunol. 36, 667–694 (2018).

    Article  CAS  Google Scholar 

  4. Cargill, M., Venkataraman, R. & Lee, S. Genes 12, 1471 (2021).

    Article  CAS  Google Scholar 

  5. Patmore, D. M. et al. Dev. Cell 54, 455–470.e455 (2020).

    Article  CAS  Google Scholar 

  6. Heerma van Voss, M. R., van Diest, P. J. & Raman, V. Biochim Biophys Acta Rev. Cancer 1868, 510–520 (2017).

    Article  CAS  Google Scholar 

  7. Zhang, H. et al. Hepatology 64, 1033–1048 (2016).

    Article  Google Scholar 

  8. Weinreb, J. T. et al. Dev. Cell 56, 627–640.e625 (2021).

    Article  CAS  Google Scholar 

  9. Pryszlak, M. et al. Cell Rep. 34, 108903 (2021).

    Article  CAS  Google Scholar 

  10. Parisien, J. P. et al. EMBO Rep. 19, e45176 (2018).

    Article  Google Scholar 

  11. Kato, K. et al. Mol. Cell 81, 599–613.e598 (2021).

    Article  CAS  Google Scholar 

  12. Rice, G. I. et al. Human Mut. 41, 837–849 (2020).

    Article  CAS  Google Scholar 

  13. Quinodoz, S. A. et al. Cell 184, 5775–5790.e5730 (2021).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Supported by NIH grants DK044533-23 and CA023168-38S1 (O.A.) and AI143265, AI100625 and AI145359 (M.G.).

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Authors and Affiliations

  1. Department of Basic Medical Sciences and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, USA

    Ourania Andrisani

  2. Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA

    Qian Liu, Patricia Kehn, Wolfgang W. Leitner & Nancy Vazquez-Maldonado

  3. Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Bethesda, MD, USA

    Kyung Moon

  4. Division of Cancer Biology, National Cancer Institute, Rockville, MD, USA

    Ian Fingerman

  5. Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, WA, USA

    Michael Gale Jr

Authors
  1. Ourania Andrisani
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  2. Qian Liu
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  3. Patricia Kehn
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  4. Wolfgang W. Leitner
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  5. Kyung Moon
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  6. Nancy Vazquez-Maldonado
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  7. Ian Fingerman
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  8. Michael Gale Jr
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Contributions

O.A. and M.G. served as co-organizers of this workshop, and wrote and edited portions of this report. O.A. designed Fig. 1 and Table 1. M.G. designed Fig. 2 and edited Table 1. Q.L., P.K., W.W.L., K.M., M.V.-N. and I.F. wrote portions of this report.

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Correspondence to Michael Gale Jr.

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The authors declare no competing interests.

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Andrisani, O., Liu, Q., Kehn, P. et al. Biological functions of DEAD/DEAH-box RNA helicases in health and disease. Nat Immunol 23, 354–357 (2022). https://doi.org/10.1038/s41590-022-01149-7

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