Extended Data Fig. 7: Induction of DSS colitis in 4-Way Bone marrow chimeric mice.
From: Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
a) Schematic of bone marrow transplantation generating 4 types of bone marrow chimeric mice, using both wild-type (WT) and Nlrp10D/D mice as donors and recipients. (b-h) Quantification of colitis severity (for (b-d), WT to WT, KO to WT, WT to KO n = 7; KO to KO n = 9; for (f and h), WT to WT, KO to WT n = 7; WT to KO n = 6; KO to KO n = 8). (b) Body weight, (c) area under the curve (AUC) of the weight change (unpaired t test), (d) colitis severity score (Unpaired t-test, *P = 0.0171, Mann-Whitney U test, ***P = 0.0009), and (e) representative colonoscopy images at day 7 after DSS initiation, (f) colon length (Mann-Whitney U test, unpaired t-test, *P = 0.0472, *P = 0.0482), (g) representative images of the colon length, (h) IL-18 ELISA of supernatants of distal colon explants at day 12 after DSS initiation (unpaired t test, Mann-Whitney U test *P = 0.0196, **P = 0.002). Mean ± SEM. *: p < 0.05, **: p < 0.01, ***: p < 0.001. Statistical test used in (c-d), (f) and (h) was two- sided. Created with BioRender.com.
