Extended Data Fig. 6: Differential immune responses to BCG vaccination in knock-out (KO) mice. | Nature Immunology

Extended Data Fig. 6: Differential immune responses to BCG vaccination in knock-out (KO) mice.

From: BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance

Extended Data Fig. 6

a and b, Serum cytokine responses in wild-type (WT) and Myd88−/− mice vaccinated with BCG intravenously at baseline, 6 h and 18 days post-vaccination (a), and day 3 post-SARS-CoV-2 challenge (b). c and d, Serum cytokine responses in wild-type (WT) and ASC−/− (c) and STING−/− (d) mice vaccinated with BCG intravenously. Data representative of two independent experiments for Myd88−/− and ASC−/− (n = 6). Two-way ANOVA with Tukey’s multiple comparison test (panel b, e, f). Multiple Mann-Whitney with Holm-Sidak multiple comparisons test (panel c, d). *, P < 0.05; **, P < 0.01; ****, P < 0.0001.

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