Extended Data Fig. 7: T and B cell clonal dynamics of TLS, peripheral blood, and tumor draining lymph nodes. | Nature Immunology

Extended Data Fig. 7: T and B cell clonal dynamics of TLS, peripheral blood, and tumor draining lymph nodes.

From: Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma

Extended Data Fig. 7

a-b, Proportion of unique T cell receptor beta chain (TCRβ) clonotypes at each TLS that were also detected in matched post-treatment (a) and pre-treatment (b) peripheral blood from patients P02, P03, P07, P08, and P12. c-d, Proportion of unique TCRβ (c) and Immunoglobulin Heavy Chain (IGH) (d) clonotypes at each TLS that were identified in the TDLN of patients OT1 and OT6. e-f, Representative upset plots showing overlap in unique TCRβ (e) and IGH (f) between tumor draining lymph node (TDLN) and microdissected TLS for patient OT1. Bottom barplots and annotation row indicate number of overlapping clonotypes between different TLS repertoires. Top stacked barplots indicate clonal composition. Bottom right stacked barplots indicate total number of unique TCRβ or IGH clonotypes identified and overall clonal composition.

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