Extended Data Fig. 6: Transcriptomic changes of synovial fibroblast post systemic IC challenge. | Nature Immunology

Extended Data Fig. 6: Transcriptomic changes of synovial fibroblast post systemic IC challenge.

From: Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge

Extended Data Fig. 6

(a) Schematic depicting the protocol. (b) Principal component analysis of synovial fibroblasts by RNA-Seq. n = 3 mice for each population. (c) Volcano plot showing differentially expressed genes in synovial fibroblasts post IC challenge. Wald test was used. (d) Heatmap of inflammatory cytokines and chemokines of synovial fibroblasts by RNA-seq. (e) Gene set enrichment analysis of the bulk RNA-seq data.

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