Extended Data Fig. 1: Mouse thymocyte scRNAseq profiling comprising the complete HSC to single positive trajectory. Mouse IELp GPCR and T cell markers expression profile.
From: An SSTR2–somatostatin chemotactic axis drives T cell progenitor homing to the intestines
(a) Top; relative positioning of the annotated cell subsets along the complete thymocyte developmental trajectory. Bottom; heatmap highlighting mRNA expression (relative to maximum per gene) of relevant genes. (b, c) Violin plots showing leukocyte trafficking receptors and T cell markers expression pattern among mouse thymocytes. Mouse IELp defined as previously indicated (see Methods). Data shown are imputed and shown as normalized log transformed expression values. The mouse thymocyte scRNAseq figure shown was generated mining a validated data set published by the Haniffa and Teichmann labs (Development Cell Atlas), as in Fig. 1a–c. The subset annotation shown in the figure was originally published by the authors. We annotated the early T cell progenitors as DN1-DN3/4 subsets based on the classic Cd44 vs Il2ra (CD25) relative expression.
