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Tissue macrophages

Portal macrophages maintain liver homeostasis

Nature Immunology volume 26, pages 989–991 (2025)Cite this article

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The liver portal area has emerged as an important region controlling liver homeostasis and diseases. Tissue macrophages in this region exert immune homeostatic function by capturing antigens, protecting sympathetic nerves and limiting neutrophil recruitment upon inflammation.

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Fig. 1: The liver portal area harbors a specific subset of macrophages.

References

  1. Bleriot, C., Chakarov, S. & Ginhoux, F. Immunity 52, 957–970 (2020).

    Article  CAS  PubMed  Google Scholar 

  2. Mengli Xu, Z. L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-025-02190-y (2025).

    Article  PubMed  Google Scholar 

  3. Gola, A. et al. Nature 589, 131–136 (2021).

    Article  CAS  PubMed  Google Scholar 

  4. Guilliams, M. et al. Cell 185, 379–396 e338 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sierro, F. et al. Immunity 47, 374–388 e376 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Miyamoto, Y. et al. Nature 629, 901–909 (2024).

    Article  CAS  PubMed  Google Scholar 

  7. Daemen, S. et al. Cell Rep. 34, 108626 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Guilliams, M. & Scott, C. L. Immunity 55, 1515–1529 (2022).

    Article  CAS  PubMed  Google Scholar 

  9. Adori, C. et al. Sci. Adv. 7 (2021).

  10. De Schepper, S. et al. Cell 175, 400–415 e413 (2018).

    Article  PubMed  Google Scholar 

  11. Zhu, Q. et al. Kidney Int. 104, 324–333 (2023).

    Article  CAS  PubMed  Google Scholar 

  12. Ural, B. B. et al. Sci. Immunol. 5, eaax8756 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was partly funded by a National Medical Research Council grant (OFIRG19nov-0017) and by a seed fund grant from the Mechanobiology Institute, National University of Singapore, to V.A.

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Authors and Affiliations

  1. Immunology Translational Research Programme, Yong Loo Lin School of Medicine. Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore

    Sheau Yng Lim, Hwee Ying Lim & Veronique Angeli

  2. Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore

    Sheau Yng Lim, Hwee Ying Lim & Veronique Angeli

Authors
  1. Sheau Yng Lim
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  2. Hwee Ying Lim
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  3. Veronique Angeli
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Correspondence to Veronique Angeli.

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Lim, S.Y., Lim, H.Y. & Angeli, V. Portal macrophages maintain liver homeostasis. Nat Immunol 26, 989–991 (2025). https://doi.org/10.1038/s41590-025-02184-w

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