Extended Data Fig. 2: Off-target sites discovered by MRE11 ChIP-seq and improved with DNA-PKcs inhibition. | Nature Methods

Extended Data Fig. 2: Off-target sites discovered by MRE11 ChIP-seq and improved with DNA-PKcs inhibition.

From: Improving the sensitivity of in vivo CRISPR off-target detection with DISCOVER-Seq+

Extended Data Fig. 2

a, VEGFA site 2 Cas9 target sites detected using DISCOVER-Seq (left) versus DISCOVER-Seq+ (right) in K562 cells. b, FANCF site 2, VEGFA site 3, or HEK site 4 Cas9 target sites detected using DISCOVER-Seq versus DISCOVER-Seq+ in K562 or HEK293T cells, at 4 h, 12 h, or 24 h after Cas9 delivery. Source numerical data are available in source data.

Source data

Back to article page