Supplementary Figure 8: TIA1 reduction increases levels of phosphorylated tau in aged PS19 mice
From: Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
A. Immunoblot analysis of PHF1 (S396/S404) phospho-tau, CP13, Tau13 (total tau), and a-tubulin levels in total (RIPA-soluble) brain lysates of 6-month P301S Tia1+/+ and P301S Tia1+/- mice. Each lane corresponds to a different mouse from the cohort. B-C. Quantification of PHF1+ (B), CP13+ (C), and total (D) tau in A. PHF1 and CP13 phospho-tau levels were normalized to total tau levels (Tau13) detected in each sample. #p= 0.0981 *p=0.0276 **p=0.0079 by unpaired Student's t-test (n=3/group). Error bars denote means ± SEM.
