Supplementary Figure 12: TIA disrupts fibrillization of pTau
From: Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
Fibrillization of GSK3|3 phosphorylated recombinant Tau was induced using dextran sulfate (DS) and RNA (pTau+Ctrl). In the presence of recombinant TIA1, pTau fibril length was significantly reduced. BSA was used as a negative control for presence of additional protein in the Tau fibrillization assay. Scatter plot of individual Tau fibril lengths (nm) measured by EM with bar at mean, box representing quartiles and whiskers representing SEM. ANOVA posthoc. *** p<0.001. Numbers assigned to data points in order in which they are measured.
