Supplementary Figure 15: Model for regulation of tau oligomerization by TIA1
From: Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
We propose that TIA1 binds and stabilizes oligomeric tau, which is a very toxic form. Reducing TIA1 removes the stabilization and allows greater production of tau fibrils. TIA1 reduction also inhibits the hyperactive stress granule response, which allows TIA1 and other RBPs to re-localize to their normal physiological functions, such as RNA splicing. The reduction in oligomeric tau and rescue of RBP functions associated with reducing TIA1 leads to neuroprotection and increased survival.
