Supplementary Figure 2: TIA1 reduction protects against presynaptic and axonal degeneration up to 9 months of age in P301S Tau mice
From: Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
A. IHC of NeuN (blue), synaptophysin (SYP, green), and neurofilament (NFL, red) in 9 month non-transgenic (WT Tau), PS19 (P301S Tau) and PS19 (P301S Tau) Tia1+/- hippocampus (CA3). Scale bar = 20 urn. B-C. Quantification of total SYP (B) and NFL (C) immunofluorescence in P301S Tia1+/+ and P301S Tia1+/- mice in A. SYP, unpaired Student's T-test (two-tailed) of P301S Tia1+/+ vs P301S Tia1+/-, *p=0.0491, N=10-13/group. NFL, unpaired Student's T-test (two-tailed) of P301S Tia1+/+ vs P301S Tia1+/-, *p=0.0441, N=11-12/group. Error bars denote means ± SEM normalized to wildtype levels equal to 1.
