Supplementary Figure 6: Locomotor activity and anxiety in GluA1^C2KI and GluA2^C1KI mice

(a) Total travel distance (meters) in the open field test (WT = 14.66 ± 1.17, n = 12 mice; A1^C2KI = 20.29 ± 1.65, n = 13 mice, **p = 0.003 compared to WT; A2^C1KI = 14.21 ± 0.83, n = 16 mice, p = 0.873 compared to WT; F_(2,38) = 7.508, p = 0.002). (b) Total time (seconds) spent in the center arena of the open field (WT = 17.17 ± 2.71, n = 12 mice; A1^C2KI = 16.25 ± 2.41, n =13 mice; A2^C1KI = 11.53 ± 3.18, n = 16 mice; F_{(2, 38)} = 1.172, p = 0.321). (c) Ratios of open/closed arm entries in the elevated plus maze test (WT = 0.89 ± 0.11, n = 12 mice; A1^C2KI = 1.19 ± 0.14, n = 13 mice; A2^C1KI = 1.07 ± 0.15, n = 16 mice; F_{(2, 38)} = 1.075, p = 0.352). (d) Ratios of time spent in open/closed arms (WT = 0.36 ± 0.06, n = 12 mice; A1^C2KI = 0.65 ± 0.20, n =13 mice; A2^C1KI = 0.53 ± 0.10, n = 16 mice; F_{(2, 38)} = 1.079, p = 0.350). One-way ANOVA followed by post-hoc Fisher’s LSD multiple comparison test was used for a-d. Data were presented as mean ± s.e.m. **p<0.01.