Supplementary Figure 6: Rett syndrome donor characteristics.
From: Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing
(top) Table describing sex, age, MECP2 mutation, post-mortem interval (PMI) in hours (h), and the brain region dissected for the three Rett donors. Samples were obtained from the Harvard Brain Bank with approval from Rettsyndrome.org. (bottom) Schematic of MECP2 protein and its two major functional domains, the methyl-binding ___domain (MBD) and the transcriptional repression ___domain (TRD). All three donors harbored nonsense mutations at R255 located within the TRD.
