Supplementary Figure 7: Epileptic bursts in the tetanus toxin model of temporal lobe epilepsy. | Nature Neuroscience

Supplementary Figure 7: Epileptic bursts in the tetanus toxin model of temporal lobe epilepsy.

From: Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Supplementary Figure 7

(a) Multi-day intercluster recording from the right hippocampus, which was injected with the tetanus toxin. (b) Bursts originate in the injected right hippocampus. They are characterized by initial high-amplitude discharges followed by a burst of rhythmic activity. (c,d) With the approaching next cluster of seizures, the duration and rate of bursts increases, as well as, propagation to the contralateral hippocampus and motor cortices of both hemispheres (n = 6/6 intercluster periods/animals; 1041.3±149.2 bursts per cluster). MCxL – left motor cortex, MCxR – right motor cortex, HippL – left hippocampus, HippR – right hippocampus.

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