Supplementary Figure 1: Current source density profile of HFA. | Nature Neuroscience

Supplementary Figure 1: Current source density profile of HFA.

From: Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Supplementary Figure 1

(a) The laminar profile of an averaged HFA cycle in the isolated CA1 is characterized by maximal field potential negativity at the stratum pyramidale. (b) Current source density profile and its contour plot (c) reveal that the HFA cycle is accompanied by an initial current sink at the pyramidal layer, which then back-propagates along the dendritic region. On a cellular level, the current source density profile corresponds to dendritic back-propagation of action potentials generated at the soma. (d) Current source density profile for an episode of HFA with superimposed band-passed (100-300 Hz) filtered signal recorded in the stratum pyramidale. (e-h) Laminar profile and current source density of HFA in intact hippocampal preparations display similar features (n=10 slices).

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