Supplementary Figure 11: Analysis of cINs transplanted in the cortex of Nod Scid mice. | Nature Neuroscience

Supplementary Figure 11: Analysis of cINs transplanted in the cortex of Nod Scid mice.

From: Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia

Supplementary Figure 11

Related to Fig. 7. The lines used are summarized in Supplementary Table 3 (a) Immunocytochemistry analysis of cINs transplanted in the cortex of Nod Scid mice after 7 months’ grafting (scale bar = 50 µm). Proportion of PV+ neurons among NCAM+ neurons between groups (n = 100 NCAM+ neurons, p = 0.7883, chi-square test). (b) GABAergic synapse analysis of healthy control versus schizophrenia cINs (n = 14 images, scale bar = 5 µm). (c) Glutamatergic synapse analysis of healthy control versus schizophrenia cINs (n = 14 images, scale bar = 5 µm). (d) Linear regression model of PCDHA expression level in cINs (x-axis) and number of inhibitory synapses (juxtaposed GFP+ VGAT+ puncta and Gephyrin+ puncta) per 100 µm2 of GFP+ cINs (y-axis). n = 14 lines.

Back to article page