Supplementary Figure 7: Contribution of functional annotation of 24 categories to the heritability of depression (n = 807,553 individuals) based on the variants within each category.
The enrichment of each functional category, shown on the y-axis, is calculated as the proportion of heritability assigned to a functional categories divided by the proportion of variants in that category (Pr(h2)/Pr(SNPs)). Error bars represent jackknife standard errors for each the estimate of enrichment, and an asterisk indicates significant enrichment after Bonferroni correction for multiple testing (Conserved P-value = 2.55 × 10−17; H3K4me1 P-value = 0.0015; Intron P-value = 0.0014). P-values were calculated using a one-sided test and tested whether there the estimate of enrichment was significantly different from zero enrichment. The dashed line represents the threshold for no enrichment.
