Extended Data Fig. 6: Altered response patterns to social and nonsocial stimuli in the mPFC of Cntnap2-/- mice.
From: Dynamics of social representation in the mouse prefrontal cortex
(a) Stimulus-evoked responses across all recorded units per stimulus, sorted by response magnitude as calculated by the change in firing rate from baseline for WT (top) and Cntnap2-/- (bottom) mice. Color gradient represents the change in firing rate from baseline, calculated over 250 ms bins. Arrows mark the time of stimulus onset and offset. (b) Response Z-score distribution calculated for all recorded units in WT (left) and Cntnap2-/- mice (right) in response to social (M/F) and nonsocial (B/P/H) cues. Circles represent maximum response of individual units to each stimulus category. Color code represents response specificity. Z score threshold (|Z|  > 2) is represented by a dashed line. Units with Z > 15 were assigned with Z = 15 for presentation purposes. (c) Number of units significantly increasing (dark) and decreasing (bright) their firing rates in response to each presented stimulus in wt (black) and Cntnap2-/- (teal) mice. (d) Relative ratio between social and nonsocial units, calculated using a continuous range of Z score thresholds for wt (black) and Cntnap2-/- (teal) mice. Arrows represent Z = 2. Linear regression analysis (0 ≤ Z ≤ 3, n = 32 measurements for each genotype), FWT(1,30) = 1088.42, P = 3.9 × 10−25, R2WT = 0.973. FCntnap2-/-(1,30) = 652.294, P = 6.5 × 10−22, R2Cntnap2-/- = 0.956; BWT = 1.106, BCntnap2-/- = 0.425, with non-overlapping 95% confidence intervals as a measure of statistical significant difference between regression lines. For all panels: *P < 0.05, M, male; F, female; B, banana; P, peanut butter; H, hexanal; CA, clean air.
